Found this in a forum
Chrome now has two startup switches that you can use:
Simply close Chrome, right-click your Chrome shortcut, click Properties, and then in the field labeled “Target:”, make it look something like this:
“…chrome.exe” –disk-cache-dir=”CACHE_DIR” –disk-cache-size=N
Where ‘CACHE_DIR‘ is the new cache location, and ‘N‘ is the cache size limit, in bytes.
Use whichever switch you need, or both. Keep in mind, however, that these features may not be completely stable yet. But you probably shouldn’t have any problem with using them.
And to anyone who’s interested, I caught gander of the existence of these switches directly from a source code file for Chrome. See here:
Disabling the cache will hurt performance of your system so use at your own risk. I have heard just going into incognito mode will do the same thing on a temp basis.