Those are not files, but directories that are created when a Windows update or patch is applied to your machine. They contain the information necessary to uninstall those patches in case you want to do that for any reason.
The probability that you need to uninstall a very old patch is very small, so you could safely delete the oldest ones (more than 3 months old, for example).
The option to copy them to a USB drive or CD/DVD is also a good idea. You could move all of them, and only copy them back in case you need to install some update or patch.