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Seems like a homework question.
Can you tell us what research you have already done and your business case for this?
Then we may be able to critique it.
Sorry. Without clarification and more details, this question makes no sense.
But as first asked, vulnerable to what? Disk crashes? Virus infections? Buffer overflow in web application servers? SQL injection? Escalation of privileges? Session hijacks? Are you needing to know about vulnerabilities in default configurations vs. fully secured configurations?
Nessus is a useful tool for many networking related vulnerabilities, and it seems like a reasonable start for you. You'll want to understand what it does. The more you learn about how it works, the more you'll see how large the scope of your question is.
Regards,Alex Christopher Johnson
Apologies, I missed your reply.
Futher to my reply.
You should look at "Penetration Testing Tools" that are both Opensource and "commercial".