So I looked up the specifications and it seems it will work just will take a little longer. IPV6 was built with this in mind though. So it will not delay DNS resolution in the future – now it might take a few extra seconds!
The Domain name system defaults to using UDP for queries and replies
with a DNS payload limit of 512 bytes. Larger replies cause an
initial truncation indication leading to a subsequent handling via
TCP with substantially higher overhead. A upward compatible
extension to DNS requests is specified which frequently permits
larger UDP responses reducing the need for use of TCP.
Read the full spec here circa 1997.