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http://itknowledgeexchange.techtarget.com/itanswers/exchange-2003-enterprise-auto-reply/ At the end of this post it does not say what to do when the server is not sending the autoreply message to email recipients that are not on the same domain.
Our organization is using Exchange Server 2007 and Outlook 2003 rich client. A group\shared mailbox has an auto reply rules that replies to all emails with a canned message. Apart from verifying that it is a real email address to spam with the reply, it has created loops with other exchange users...