Make sure that all parent folders for Application Data permit read access for the requisite users. Verify that each user has read permissions for each directory in the path and that GPO policy isn’t overriding these permissions. Adobe recognizes that this workaround isn’t optimal in some enterprise settings.
Make sure Windows 7, the Application Data folder’s Everyone account has a special permission of Deny. Remove the checkmark for Deny
Map UNC paths such as \\server\profile\%USERNAME% to a drive letter such as U:\profile\%USERNAME%
On Windows 7, verify the LocalLow directory exists at C:\Users\<user>\AppData with Read and Write permissions
Try out the above !