See information on Printers from Zebra/Eltron for some details.
Because the S4M is a host-based (i.e., Windows-only) printer, you need a PC with a printer session. This may be set up as an iSeries Access printer session, but from the notes (as with essentially all Windows-only printers):
Note: Configuring a PC5250 printer session without Host Print Transform (HPT) and without a Printer Definition Table (PDT) file is most likely to print successfully. However, you will not be able to print *AFPDS spooled files because that requires using Host Print Transform, and you will have limited control over the formatting of your output (including limited control over the font selection). Therefore, configuring to print to a Host-Based Printing, Proprietary (GDI), or Windows GDI printer is considered unsupported, as would printing to any other host-based printer. (And…) Because they use a proprietary printer data stream, they do not work with Host Print Transform (HPT) or a PC5250 Printer Definition Table (PDT) file. Because they will not work with HPT, they also will not work to print *AFPDS spooled files through the AFPDS-to-ASCII Transform code within HPT. The only way to get a host-based printer to print IBM i family spooled files is to attached it to a host computer and then use printer emulation software, such as a PC5250 printer session, to print the spooled file through the host-based printer driver.