Try Truecrypt - http://www.truecrypt.org/
Main Features:
* Creates a virtual encrypted disk within a file and mounts it as a real disk.
* Encrypts an entire partition or storage device such as USB flash drive or hard drive.
* Encrypts a partition or drive where Windows is installed (pre-boot authentication).
* Encryption is automatic, real-time (on-the-fly) and transparent.
* Parallelization and pipelining allow data to be read and written as fast as if the drive was not encrypted.
* Provides plausible deniability, in case an adversary forces you to reveal the password:
Hidden volume (steganography) and hidden operating system.
* Encryption algorithms: AES-256, Serpent, and Twofish. Mode of operation: XTS.
Last Wiki Answer Submitted: September 12, 2009 8:04 am by BlankReg12,265 pts.
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SafeHouse Explorer makes your secret files invisible and hides them from snoopers, intruders and anyone else who doesn’t have your permission to view them.
SafeHouse Explorer uses passwords and maximum-strength 256-bit advanced encryption to completely hide and defend your sensitive files, including photos, videos, spreadsheets, databases and just about any other kind of file that you might have.
SafeHouse Explorer can protect files residing on any drive, including memory sticks, external USB drives, network servers, CD/DVDs and even iPods. We also support U3 Smart Drives.
SafeHouse Explorer creates hidden private storage areas on your local hard drive or external media to hold your confidential files. Your files are completely invisible until you enter your password. After you enter your secret password, you access your files using SafeHouse Explorer’s familiar drag-and-drop Explorer-like interface.
SafeHouse Explorer is another option.
WHAT IS SAFEHOUSE EXPLORER?
SafeHouse Explorer makes your secret files invisible and hides them from snoopers, intruders and anyone else who doesn’t have your permission to view them.
SafeHouse Explorer uses passwords and maximum-strength 256-bit advanced encryption to completely hide and defend your sensitive files, including photos, videos, spreadsheets, databases and just about any other kind of file that you might have.
SafeHouse Explorer can protect files residing on any drive, including memory sticks, external USB drives, network servers, CD/DVDs and even iPods. We also support U3 Smart Drives.
SafeHouse Explorer creates hidden private storage areas on your local hard drive or external media to hold your confidential files. Your files are completely invisible until you enter your password. After you enter your secret password, you access your files using SafeHouse Explorer’s familiar drag-and-drop Explorer-like interface.
I’ve been using BitLocker for thumb drive encryption and it’s been working well so far. You can also use PGP disk encryption.