This online documentation explains how to plan a web-based application hosted by Domino.
<a href="http://publib.boulder.ibm.com/infocenter/domhelp/v8r0/index.jsp?topic=/com.ibm.designer.domino.main.doc/H_PLANNING_A_WEB_APPLICATION_OVER.html">Planning a traditional (Domino) web application</a>
However, If by "Open in http link" you mean that you want Lotus Notes to start and open to this application from an web browser, then you need to write a link to the application using the notes:// protocol. To easily get a notes:// protocol link to a Notes application, right click any document in the application and display the Document Properties, then choose the "+" tab. On the "+" tab, you will find a window displaying the document identifier, which includes the file unique ID, view ID and document ID. Copy the notes indentifier, then remove the document ID and view ID. Use the remaining portion of the notes:// protocol link for the link in the web browser. When clicked, Lotus Notes will launch (if needed) and display the application.
Comment: If the user does not have the application on their Notes workspace, use of the notes:// proptocol link to open it will work, but the application icon will not be added to their workspace.
Hope this answers your question.