according to sophos’ website their antivirus supports windows, Mac OS X, Linux, Unix, Netware and OpenVMS, NetAPP Storage systems and mobile products.
see there site here: http://www.sophos.com/products/enterprise/endpoint/security-and-control/
I’d go with Symantec Endpoint Protection, they’ve won contracts with the feds for the past 3 years to date. Although, I must say McAfee won the 2012 contract, just because of their self-learning Host Based Intrusion Prevention. Symantec has this but to my knowledge they don’t have one that learns from neighboring networks and all those other goodies yet. Not sure if McAfees’ self-learning HIPS is available to the public/commercially yet. Goodluck!