Quickbase is a browser accessed database building application. It allows users to build relational data structures with limited previous experience and has reporting functions built in. For many users it replaces the need for multi-user spreadsheets that are difficult to update.
Quickbase charges a monthly fee based on users and storage. Any browser can access quickbase, uptime is very good and security seems to be good as well.
My company and 40 users have had little trouble in our one year of use.