Is this event id 1009?
I found this comment from another site:
GhostRyder2112:I found the resolution to this issue, or more importantly my particular issue. The permissions were not set correctly in the GPO. Once they were set mail started to flow. Ive included the steps I took to find the solution below.
SYMPTOMS: Mail sits in the outbox on newly installed Exchange Mailbox 2007 and Exchange Hub 2007 servers.
1. Event ID 1009
RESOLUTION: Turned up Debug Trace Logging in EXTRA.exe on the Mailbox server for StoreDriver, and All Categories. Stopped restarted the Microsoft Exchange Mail Submission Service, and waited for event to be logged in event log.
In the trace log we had this line:
SeqNo TraceType Component Tag Message
24 Debug StoreDriver BridgeheadPicker Found /o=XYZ/ou=Exchange Administrative Group/cn=Configuration/cn=Servers/cn=ServerName as the next server
25 Pfd StoreDriver MailSubmissionService EMS 22427 SubmitMail for mailbox 00000000-0000-0000-0000-000000000000 at entry 64
44 Debug StoreDriver MailSubmissionService Submission failed. Error: ServerNotAvailable, Diagnostic Information:Rpc Error 5
Using the Group Policy MMC go to Local Computer Policy / Computer Configuration / Windows Settings / Security Settings / Local Policies / User Rights Assignment. Under Access this computer from the network make sure the following groups are added – Everyone, Administrators, Backup Operators, Power Users, and Users.
GhostRyder2112:I modified the GPO that was attached to the servers which pushed the settngs to the “Access this computer from the network” area.