My first impulse would be to say yes but more accurate would be to say "it depends."
What are you doing? If you run some kind of Domino applications aside from mail then the answer would depend on what those applications do. If this is just mail files then probably yes, though you should care about disk size because corporate policy will determine how much disk space you need. Size limits on mail files? Age limits on mail in the files? Attachment size limits? People are packrats and will keep 5 year old mail, "just in case," unless there are specific policies in place. You also may want to consider the possibility of having 2 CPUs in the server. You don't say what brand of server this is, what version of Domino or what OS you want to run and all of those should have some weight on sizing. I can point you to the following URL, which talks about how to size an IBM xSeries server with Domino 6.5 - http://searchdomino.techtarget.com/whitepaperPage/0,293857,sid4_gci1006626,00.html
Last Wiki Answer Submitted: July 5, 2005 3:32 pm by EricHarris0 pts.