Corrupt full access permissions Exchange 2010

5 pts.
Tags:
Microsoft Exchange 2010
Microsoft Exchange errors
I have a user trying to access a shared mailbox but they were getting an error saying: 'the set of folders cannot be opened. Microsoft Exchange is not available.Either there are networks problems or the Exchange server is down for maintenance' Removing the full access permissions and re-adding them has resolved the issue. This is affecting multiple users, for various different shared mailboxes. Does anyone know what might cause this?

Software/Hardware used:
Windows 2008 server R2 With exchange 2010, running on vSphere

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