Yes, you can do that. There are several options: Native apps, Java apps, HTML5 apps, all of them supported on Mac OS.
Here are some links you might find useful:
Native apps (Using Qt/QML and an eclipse-based IDE)
As for the easiest way, it depends on your team’s knowledge and experience. For me, that would be the native option, since I have worked with Qt and QML in the past, and I like them a lot, but that is just my personal preference.