So as many know Microsoft did not include any support for 16 bit applications in it’s 64 bit windows Operating Systems. What does this mean if you want to have a 64 bit OS but still need to run 16 bit applications? Well you have a couple of choices.
You could certainly use a product like VMware workstation or HyperV or such to run a virtual machine within your system that uses a guest OS that can run the software. This is a great solution but not a free solution.
If you are looking for a free solution I can recommend using an application called DosBox (http://www.dosbox.com/). This runs great inside my Vista 64 box and is completely free. I highly recommend it.