As someone who writes an astronomical amount of content each week, my eyes tend to get fatigued from staring at my monitors all the time. Making the transition from CRT monitors to LCD monitors a few years ago really helped out a lot, but I always wished that there was an easy way to reduce eye strain even more.
Fortunately, I just stumbled on to a new feature in Windows 7 that helps you to calibrate your display for the optimal level of contrast. The calibration wizard also comes with a mechanism for tuning clear type fonts so that you can use the fonts that are the easiest to read. You can access the calibration wizard by going to the Control Panel and double clicking on the Calibrate Display Color icon.